About the Lab
J. Virol. 2014
|Buckingham et al
Dr. Charles Grose is an infectious disease specialist and a virologist at the University of Iowa Children's Hospital. He received his postdoctoral virology training in the laboratories of Marshall Horwitz, Barry Bloom, and Bernard Fields at the Albert Einstein College of Medicine in New York City.
Since 1980, he and his students and collaborators have published more than 200 scientific papers on the herpes viruses with a particular emphasis on the varicella-zoster virus (VZV). VZV is the pathogen that causes chicken pox in early childhood and zoster later in life. Following publication of a paper in 2009 by Takahashi et al, the Grose lab has turned its attention to a cellular process called autophagy. Autophagy refers to the process by which cellular organelles are engulfed by a double walled membrane called an autophagosome which then fuses with a lysosome where the engulfed cellular material is degraded. Autophagy is carried out by a large number of proteins (over 30 proteins have been identified in yeast) and is involved in a large number of cellular processes,e.g.,: scavenging amino acids and metabolites during cellular starvation; degrading mitotic protein complexes after cellular division and it has been found to be induced or blocked by a number of different DNA and RNA viruses.